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KMID : 0043320130360080927
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Archives of Pharmacal Research
2013 Volume.36 No. 8 p.927 ~ p.932
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Alkaloids from Lycoris caldwellii and their particular cytotoxicities against the astrocytoma and glioma cell lines
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Cao Peng
Pan Dong Sheng
Han Song
Yu Chun Yong
Zhao Qing Jie
Song Yan
Liang Yong
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Abstract
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Phytochemical investigation of the ethanol extract of the bulbs of Lycoris caldwellii afforded four new alkaloids, (+)-N-methoxylcarbonyl-nandigerine (1), (+)-N-methoxycarbonyl-lindcarpine (2), (+)-10-O-methylhernovine N-oxide (3), and (+)-3-hydroxy-anhydrolycorine N-oxide (4). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. All the alkaloids were in vitro evaluated for their cytotoxic activities against eight tumor cell lines (BEN-MEN-1, CCF-STTG1, CHG-5, SHG-44, U251, BGC-823, HepG2, and SK-OV-3). Alkaloids 1 and 2 exhibited particular cytotoxic activities against astrocytoma and glioma cell lines with IC50 of 9.2?11.3 μM and 10.4?12.2 μM respectively.
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KEYWORD
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Lycoris caldwellii, Amaryllidaceae, Alkaloids, Cytotoxicity
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